Organic

Natural Product-based Drug Discovery (#66)

Natural products and their derivatives account for 50% of new chemical entities (NCEs) approved for the treatment of human diseases. For instance, of the 118 small molecule NCEs for antibacterial indications identified in the 30 years between 1981 and 2010, 66% were from either natural products (10, 8.5%) or natural product derivatives (68, 57.6%). Natural products chemistry, natural products isolation and biological evaluation have made significant contributions as an important source of new drug "leads" and approved therapeutics. The general goals of this symposium are to have a productive discussion of a broad range of areas that are covered by natural products, and to exchange knowledge and information for future expansion of the field. The topics of this symposium include, but are not limited to, isolation and structure determination of bioactive natural products, chemical or biosynthetic approaches of complex compounds to supply sufficient amount of material, chemical biology using natural products as tools, and development of drugs using them as leads. The six 1/2 day sessions (6 x 3.5 hours) will offer over 40 lectures on this subject by eminent scientists from both academia and industry from around the Pacific Rim. In an evening poster sessions (2 hours), 50 posters will be presented.
Last update: Dec 28, 2015