Homeostasis of Transition Metal Ions in Biological Systems (#47)

Transition metal ions and metalloproteins play crucial roles in meeting the energy demands of the cell by playing roles in intermediary metabolism and in signal transduction processes. Although they are essential for biological function, metal ion bioavailability must be maintained within a certain range in cells due to the inherent toxicity of all metals above a threshold. This threshold varies for individual metal ions. Homeostasis of metal ions requires a balance between the processes of uptake, utilization, storage, and efflux and is achieved by the coordinated activities of a variety of proteins including extracytoplasmic metal carriers, ion channels/pumps/transporters, metal-regulated transcription and translation proteins, and enzymes involved in the biogenesis of metal-containing cofactors/metalloproteins. In order to understand the processes underlying this complex metal homeostasis network, the study of the molecular processes that determine the protein-metal ion recognition, as well as how this event is transduced into a functional output, is required. In this symposium, we will discuss the structural and functional relationships for metal chaperones, transition metal ion-sensing transcriptional regulators, transition metal ion transporters, and protein machineries for biogenesis of metalloproteins to understand the molecular mechanisms of metal ions homeostasis in both prokaryotes and eukaryotes.
Last update: Dec 28, 2015