Synthetic Modulators of Protein-Protein Interactions (#461)
Traditional pharmaceutical efforts have made great strides by exploiting the comparatively tractable landscape of enzyme active sites or other localized protein pockets to design potent agents that influence a broad range of disease relevant protein functions. Despite these gains, a much broader landscape of medicinally significant interactions remain beyond the reach of small molecules, since they depend on protein-protein interfaces (PPIs) spread over large contact surfaces. Such protein-protein complexes are essential for normal and abnormal cellular functions. This symposium will center on cutting edge methods for the comprehension and manipulation of PPIs using a wide range of methods, and on the prospects for therapeutically viable interventions.
Last update: Dec 28, 2015