Inorganic

Telomeres and other G-quadruplex Structures as Targets for Metallodrugs (#459)

There is growing interest in the wide variety of G-quadruplex structures found in nature, such as those present in telomeres, in view of their role in the cell aging process and their potential to serve as targets for novel anticancer agents. This has been accompanied by a growing awareness of the prevalence of highly conserved G-rich sequences capable of forming quadruplexes in all eukaryotic genomes. This highlights the need for new techniques of determining what precise G-quadruplex structure is present in solution under a given set of conditions. In addition, there has been an surge in the number of scientific papers published which focus on the synthesis and evaluation as potential anticancer agents, of metal complexes that can selectively bind to these structures and also inhibit the enzyme telomerase or affect gene expression. Pacifichem 2015 will bring together researchers from Pacific Rim countries as well as other regions to exchange ideas and information on the above areas and other aspects of G-quadruplex research.
Last update: Dec 28, 2015