Organic

Asymmetric Supramolecular Catalysis (#451)

Supramolecular systems prepared via the self-assembly of multifunctional subunits are of interest from a variety of functional perspectives including that of catalysis. This symposium will focus on recent advances in the design of chiral supramolecular catalysts for asymmetric catalysis.

It is the goal of all chiral small metal- and organocatalyst designs to (i) create a “chiral catalytic pocket” (topography) around the site of catalysis to direct the reaction’s stereochemical course, and (ii) impart the appropriate electronic characteristics at the catalytic metal center or through precisely positioned organocatalytic functionality to effect efficient catalysis. Hydrogen-bonding, metal complexation and non-bonded interactions are structural motifs used in nature to direct the three dimensional assembly of a protein framework to accomplish these goals, that is, position the active site functionalities and create the chiral pocket, for efficient biocatalysts. The same interactions are used with increasing success to define topography and promoted reactivity in chiral supramolecular chemocatalysts. The result is that a variety of useful reactions, for example, asymmetric hydrogenation, hydroboration, hydroformylation, hydrolysis, etc., can be efficiently promoted by chiral supramolecular catalysts.

While great strides have been made toward mimicking the catalytic behavior of enzymes with supramolecular chemocatalysts, other than the design of efficient screening protocols, much remains to be learned about the design principles and optimization strategies for chiral supramolecular catalysts. This symposium seeks to highlight the current state of the art of its practice and the current thinking on the design of chiral supramolecular catalyst systems for asymmetric catalysis.
Last update: Dec 28, 2015