Chemical Biology of Protein-Lipid Modification (#421)

Protein-lipid modification is a post-translational event that occurs on many proteins involved in key signaling processes within cells. Examples of such modifications include the attachment of fatty acids, isoprenoids and sterols to specific residues located within certain proteins. Since these lipid-modified polypeptides are involved in regulating many cellular processes including growth, differentiation and cellular metabolism, there is tremendous interest in this field. Synthetic chemical probes in concert with enzymological experiments have provided important insights into this key cellular process. Numerous clinical trials of small molecules that interfere with this process have been carried out. This symposium will showcase the latest developments in this exciting and emerging field. Speakers will include synthetic chemists, biochemists, crystallographers and molecular biologists. The symposium will focus on the following areas related to protein-lipid modification:

1) Chemical synthesis of alternative substrates and chemical probes
2) Enzymology of enzymes involved in protein-lipid modification
3) Proteomics, imaging and identification of modified proteins
4) Structural studies
5) Lipid-modified proteins in disease
6) Inhibitors and the development of therapeutic agents
Last update: Dec 28, 2015