The Bio-Coordination Chemistry of Nitric Oxide and Its Derivatives: Mechanisms of NOx Generation, Signaling and Reduction in Biological Systems (#371)

Nitric oxide was found in the 1980s to be a signaling molecule in the human body, and also produced as a central immune defense agent in humans. This discovery was so important that it was awarded with a Noble Prize in physiology/medicine in 1998. Later it was discovered that nitrite, nitric oxide and nitrosothiols all interconvert in the human body. Importantly, the production, metabolism, and sensing of nitric oxide in mammals is mediated by transition metal centers. In addition, transition metals (especially iron and copper) are also of key importance for the interconversion of NO, nitrite and nitrous oxide in the biogeochemical nitrogen cycle. Because of this, the coordination chemistry of nitric oxide and its derivatives with transition metal centers has been a hot topic in bioinorganic chemistry in the last decade.
This symposium will focus on two important aspects of this topic, the MECHANISMS of important proteins and enzymes involved in the generation, sensing and degradation of NO in biology, and the STRUCTURES and reactivities of the key intermediates of these transformations. This symposium further covers important derivatives of NO, in particular HNO, nitrite, and nitrosothiols.
Last update: Dec 28, 2015