Physical, Theoretical & Computational

Dissociation of Biomolecules in the Gas Phase for Structural Characterization (#352)

Biomolecules such as peptides, oligosaccharides, and lipids, which play important roles in biology, form specific structures that dictate function. Determination of the precise structures of these biomolecules is not only challenging, but also necessary to understand how they interact with substrates. Recent developments in mass spectrometry allow the isolation of biomolecules in the gas phase for the subsequent characterizations using various dissociation techniques to obtain structural information. The symposium will deal with the dissociation of biomolecules in the gas phase via radical-directed, electron-transfer, photoinduced, and collision-induced processes, each of which contributes particular strengths that facilitate structural characterization and isomer disambiguation. The specificity of bond cleavage upon activation of biomolecules by radical, electrons, light or collision present significant challenges to both experiment and theory to describe the formation of the activated complexes and their evolution into products. The symposium will focus on experimental and theoretical studies of activation and dissociation processes of biomolecules at the molecular level.
Last update: Dec 28, 2015