Bioorthogonal Chemistry: Tools and Applications in Chemical Biology (#343)

Bioorthogonal chemistry encompasses the development of functional groups that are inert to biological molecules, conditions, and systems, but that can be induced to rapidly make or break bonds on demand. High reactivity and selectivity is required in moving these organic reactions from the flask into living systems. The functional groups used in bioorthogonal reactions have been incorporated into a variety of biomolecules using biochemical, metabolic and genetic strategies. The type of chemoselectivity required for bioorthogonal reactions enables the invention of powerful and sophisticated methods for studying biological systems, engineering new components for biological use and re-designing biological systems for unnatural purposes. Bioorthogonal chemistry also gives synthetic chemists tools to create molecules that interact with biological targets in well-controlled ways. Such capabilities of chemical control in complex environments have found application in non-biological systems as well.

This symposium will bring together developers and users of bioorthogonal processes for an historical perspective on the field and a look at exciting developments to come. Contributions will be divided into four theme areas:
1) new methods to introduce orthogonal chemical elements into biological systems (proteins, nucleic acids, glycans, lipids, cofactors)
2) new or improved bioorthogonal reactions
3) biological applications of bioorthogonal chemistry, including biophysical probes
4) non-biological applications of bioorthogonal chemistry: materials that benefit from bio-orthogonal connections
Last update: Dec 28, 2015