Agrochemistry, Environmental, and Geochemistry

Environment and Gene Interaction (#336)

Genetic and epigenetic effects of xenobiotic exposures have the potential to affect organogenesis, and to alter physiological function. Some of these effects may be trans-generational and may have implications for adaptation.
This symposium will address topics of organism exposure to xenobiotics and resultant effects on genes and gene expression in aquatic and terrestrial organisms. The symposium will emphasize ubiquitous contaminants, like plasticizers flame retardants and perfluorinated compounds, and will also include exposures to natural stressors that may exacerbate or mitigate certain adverse effects. Examples of effects include organogenesis (liver, pancreas, gonads) during development and the respective physiological functions (metabolism and fecundity) in later life. Presentations will explore Adverse Outcome Pathways (AOPs) for organ systems or whole organisms that are exposed to different important xenobiotics. AOPs aim to establish links between molecular initiating events or even chemical structure-related properties (e.g. QSARs) of a toxicant and subsequent apical outcomes with the ultimate goal to develop predictive models that will enable making predictions from such molecular effects at the gene-expression or protein level to population (wildlife) or individual health (human) responses.
Last update: Dec 28, 2015