Mechanochemistry and Solvent-free Synthesis (#322)

In the past decade solvent-free methodologies of chemical synthesis, and in particular mechanochemistry, have emerged as general, highly efficient and versatile alternatives to conventional solution-based and solvothermal approaches to organic chemistry. The outstanding potential of mechanochemical and other types of solvent-fee reactivity in reducing energy input and significantly reducing, or even completely eliminating, the use of bulk solvents in chemical synthesis has been clearly demonstrated. Modern solvent-free chemistry now offers general procedures for transition metal- or organocatalysis, enantioselective synthesis, multi-step syntheses of medicinal and pharmaceutical targets and assembly of complex (supra)molecular systems such as cages, covalent frameworks and rotaxanes. Despite these major advances, however, mechanosynthesis is still considered as a "black box" technique whose potential in organic synthesis is poorly known to researchers. This Symposium will highlight the cutting-edge advances in synthetic applications and mechanistic understanding of solvent-free and mechanochemical synthesis, and expose this area to a general audience of researchers interested in green and sustainable chemistry. Of particular interest will be solvent-free and mechanochemical techniques applied in the contexts of enantioselective and organocatalytic synthesis, as well as for the synthesis of targets interesting for their pharmaceutical, medicinal and materials applications. So far, the following speakers have agreed to join this Symposium: Koichi Komatsu, Mamoru Senna, Guan-Wu Wang, Davor Margetic, James Mack, Len MacGillivray and Evelina Colacino.
Last update: Dec 28, 2015