Chemical Glycosylation: Methods and Mechanisms (#306)

Most naturally occurring glycans are complex molecules that are difficult, impractical or impossible to isolate from nature as single glycoforms in high purity. Moreover, the quantities available through isolation are generally too small for detailed biochemical or structural biological investigations. Such studies, therefore, rely instead on synthetic glycans and, as a result, the field of synthetic oligosaccharide chemistry is undergoing a renaissance. Notably, a number of efficient methods for oligosaccharide assembly have been developed over the past decade. In addition, an increasing number of mechanistic studies of chemical glycosylations have been carried out, which has allowed rational optimization of these reactions and improved access to a diverse range of glycans. This symposium will bring together leaders in the area for a discussion of recent advances in this important field. In particular, the focus will be on new methods for stereoselective glycoslyation, mechanistic work on these reactions, and the development of methods that provide rapid access to suitable building blocks for oligosaccharide assembly. Chemists in Pacific Rim countries have played a leading role in this area and the majority of speakers will be from these countries and will include both senior leaders in the field and younger emerging investigators.
Last update: Dec 28, 2015