Bench to Bedside: Chemistry of Health Care

New Antibacterial Agents (#236)

New antibacterial agents are needed to treat patients with infections caused by bacteria that are resistant to current drugs. The discovery and development of new antibacterial drugs has proven to be problematic as evidenced by a weak development pipeline. In particular, there are few options for treating Gram-negative bacteria with multiple drug resistance. This symposium will focus on new approaches and programs with the potential to yield new antibacterial drugs. Topics will include: new compounds in current drug classes with expanded spectrum, compounds that inhibit bacterial resistance mechanisms directly (e.g. beta-lactamase inhibitors or efflux pump inhibitors), and novel drug classes that inhibit new or underexploited targets. A particular emphasis will be given to new approaches that solve key problems in advancing an antibacterial drug.
Last update: Dec 28, 2015