Bench to Bedside: Chemistry of Health Care

Chemistry of Molecular Imaging (#215)

Molecular imaging (MI) plays a major role in modern healthcare. MI tools and techniques are critical for the diagnosis of disease and monitoring delivery of therapeutic interventions. Imaging modalities including optical, computed tomography (CT), magnetic resonance (MR), ultrasound, PET (positron emission tomography) and SPECT (single photon emission computed tomography) are utilized in the diagnosis and treatment monitoring of cancer, cardiac disease, and neurological disorders among others. Contrast agents, imaging reporters and targeted molecular probes are essential for in vivo imaging of receptors or biochemical pathways. This symposium will focus on the medicinal and synthetic chemistry underpinning probe development and application. The symposium will highlight the spectrum of molecules that carry the imaging tag(s) (e.g. nuclear, optical, MR, dual modality, etc.) to a specific biological target, the novel methods for preparation of these agents as well as preclinical and early clinical evaluation. The following topics will be included: a) automation, solid-phase and microfluidic chemistry; b) imaging agents for drug development; c) dual modality (e.g. PET/MR, PET/Optical) probes and imaging; d) nuclear and non-nuclear imaging agent preparation. Molecular imaging agents span the full spectrum of discovery and translational research to bring new materials forward, enabling diagnostic and therapeutic development.
Last update: Dec 28, 2015