Bench to Bedside: Chemistry of Health Care

In Vivo Chemical Strategies for Functional and Translation Studies of Biological Networks and Pathways (#212)

Chemical techniques have been extensively applied to the study of basic cellular functions as well as to better define specific aspects of disease pathologies. Efforts using selective inhibitors and small molecule imaging agents have resulted in significant advances in our understanding of the function of diverse protein targets. The aim of this symposium is to discuss recent progress in the application of chemistry and chemical tools to study living systems. This includes the design and synthesis of synthetic probes and fluorescent tags and their application in cellular physiology, clinical diagnosis, in vivo imaging and in vivo molecular manipulation. Work in this field involves collaborative and integrative efforts from scientists of diverse but complementary expertise. The use of such functional and translational approaches has led to an increase in our understanding of living systems. Yet, despite successful application of chemical tools in many complex systems, many daunting challenges still remain to be addressed. Perhaps the greatest challenge remains the development of well-defined molecular markers that can be used in clinical applications. The purpose of this symposium is to summarize the most recent developments in this area, foster new approaches towards in vivo molecular modulations, manipulation, imaging and diagnosis.
Last update: Dec 28, 2015