Fluorescent and Luminescent Proteins: New Chemistries and New Functions (#180)

Since the cloning and characterization of GFP about 20 years ago, fluorescent and luminescent proteins have become indispensable in modern biology research. Their genetically encodable and light-emitting nature has revolutionized biology by allowing the visualization of cells, proteins, and biochemical events. Detailed understanding of the chemical mechanisms involved in light generation has helped drive performance improvements and application development. This symposium will cover recent advances in understanding the chemistry of light-emitting proteins, as well as the development of new functions for light-emitting proteins in biotechnological applications.

Topics will include:
(1) chemical mechanisms underlying improvements in traditional fluorescent and luminescent proteins, such as new noncovalent interactions in wavelength tuning, photochemical reactions in chromophore photoconversion, and structural basis of improved luciferases;
(2) chemical basis of light emission from new classes of engineered fluorescent proteins, such as phytochromes, phototropins, rhodopsins, and fatty acid binding proteins; and
(3) adaptation of fluorescent and luminescent proteins to sense and control biochemical processes in the cell, such as dynamic visualization of ultrastructure, sensing of molecular interactions, ions, or electrical potentials, and control of protein functions.

A substantial fraction of talks will be selected from submitted abstracts to promote the dissemination of new ideas from all participating laboratories.
Last update: Dec 28, 2015