New Tools and Methodologies for the Characterization of Biomolecular Interactions (#15)

Non-covalent interactions of biological molecules are pivotal to regulation of cellular processes. They are also playing increasingly-important role in pharmaceutical discovery and drug development. However, these interactions are often transient and relatively weak, making them difficult to detect and even more challenging to analyze quantitatively. New analytical tools are required to meet these challenges and to facilitate the characterization of the complex networks of non-covalent interactions that govern biochemical function in the cell. This symposium aims to highlight the significant contributions made by new analytical technologies to quantitative and qualitative measurements of interactions between biological macromolecules. A diverse range of methodological platforms will be included, enabling in-depth discussion about future development trends in this area. Emphasis will be on emerging techniques with a demonstrated capability to obtain unique insights into the intricate interplay between biological molecules. Research topics to be covered are but not limited to:
1) Analytical separations for quantitative measurements of kinetic and equilibrium parameters of molecular interactions; 2) Optical spectroscopy, microscopy, and NMR methods for interaction evaluation; 3) Mass spectrometry and ion mobility methods for qualitative and quantitative analysis of bimolecular interactions; 4) Theoretical and computational approaches for assessment of interaction forces; 5) Mass-spectrometry-based methods for analysis of interaction networks and post-translational modifications; 6) Analysis of biological complexes under native conditions.
Last update: Dec 28, 2015