Marine and Freshwater Toxins: Detection, Structure, and Pharmacology (#138)

Marine and freshwater toxins are an intriguing and challenging topic for analytical, natural product, and biological chemists. Posing worldwide public health problems and largely microbial in origin, many of the most toxic congeners are produced by organisms in the Pacific Rim. This symposium is primarily analytical in nature and includes extensive coverage of crucial developments in LC-MS/MS and screening methods based on ELISA, together with accelerated analyte extraction methods. Related topics of interest such as applied organic chemistry, pharmacology, toxicology, and cell biology are all integrated into the overall analytical equation. Development of highly selective antibodies for ELISA-based detection methods were, for example facilitated by intermediate CTX structure fragments, by-products in the extremely challenging synthesis of these stereochemically complex compounds. Functional assays such as cell assays and receptor binding assays are generally most powerful in combination with LC-MS/MS, providing a powerful marriage between structure and function and allowing trace level detection and confirmation. This session will highlight the latest advances from the leading researchers in the field.

Confirmed invited speakers include Takeshi Yasumoto, Ron Manger, Ann Abraham, Clem Furlong, Deng-Fwu Hwang, Paul K. S. Lam, Richard Lewis, Naomasa Oshiro, Helen Phang, Toshiyuki Suzuki, Takeshi Tsumuraya, Shuji Yamashita, and Mari Yamashita.
Last update: Dec 28, 2015