Angela Gronenborn , University of Pittsburgh, 1051 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA, US, 15260 | Mitsuhiko Ikura | Weontae Lee | Raymond Norton | Ichio Shimada | Tai-Huang Huang

Since the mid-80's, the application of NMR spectroscopy to the study of biological macromolecules has expanded immensely as techniques have been refined and novel methodologies developed. Today, biological NMR spectroscopy is a highly sensitive method to not only examine basic structure-function relationships of individual biological macromolecules but also to probe the supramolecular structures of protein complexes, inter and intramolecular dynamics and catalysis, and the metabolome of various organisms, including humans. In our proposed symposium, we will discuss the technological and methodological advances that have allowed these latest applications of NMR and examine the frontier of NMR spectroscopy in terms of future application, technique, and next-generation methodology. Specific topics will include motion and catalysis, supramolecular structures, approaches to integrate NMR-based structure determination with rapidly growing databases of protein sequences emerging from genome sequencing, and fast structure determination.