Christopher Welch , Merck & Co., Inc., Christopher J. Welch, Ph.D., Scientific Head, Separation & Purification Center of Excellence, Department of Process Research, RY 801 C101, Merck & Co., Inc., Rahway, NJ 07065, Rahway, NJ, US, 07065 | Myung Hyun | Arvind Rajendran | William Farrell

This symposium will focus on the important emerging "Interface between Organic Synthesis and Chromatograhpy", and will consist of four linked sessions. Session #1 - High Throughput Analysis in Support of Organic Synthesis (organizer: Christopher Welch, Merck, USA)- highlights recent trends in miniaturized, parallel, and fast chromatographic approaches to support high throughput experimentation, especially catalyst and enzyme screening. The session will feature detailed descriptions of high throughput experimentation workflows (catalysts, enzymes, crystallization, flow chemistry) and the supporting high throughput chromatographic techniques used for analysis. Session #2 - Synthesis and Evaluation of New Chromatographic Stationary Phases (Organizer: Prof. Myung Ho Hyun, Pusan National University, South Korea) - This session will provide a survey of the synthetic chemistry behind the preparation of new chromatographic stationary phases, with some description of evaluation and performance. This is an exciting area of organic synthesis that more traditional synthetic chemists are beginning to enter. Session #3 - Small Scale Preparative Chromatography in Support of Discovery Synthesis (Organizer: William Farrell, Pfizer, USA) - This session highlights recent advances in high throughput purification tools and use in discovery chemistry programs - descriptions of current state of the art instruments capable of purifying tens of thousands of compounds per year, and how they are used to support synthetic programs in pharma. Session #4 - Large Scale Preparative Chromatography in Development and Commercial Synthesis (Prof. Arvind Rajendran, Singapore National University) This session will focus on integration of large scale chromatography into commercial manufacturing or large scale development. Combination of new equipment/capabilities for Preparative Chromatography at multi-ton scale with strategy for use in organic synthesis - presentation of several case studies