A wide variety of biomaterials depend on metal ions for their diverse array of properties and functions. Examples include small molecule activators, catalysts, gas sensors, metal ion storage assemblies, energy conversion systems, and regulators of physiological function. The proposed symposium on molecular design in bioinorganic chemistry will focus on the following four themes:
1. Molecular Design of Functional Models for Metalloproteins: The construction and study of synthetic models has provided fundamental insights into metalloprotein structure and function. These models may lead to practical applications, such as the development of new catalysts. The design, synthesis, reactivity and mechanistic pathways of synthetic models will be discussed.
2. Molecular Design and Modification of Metalloproteins: Direct modification of metalloproteins through de novo design, mutagenesis, and synthesis can provide crucial insights into biological activity, as well as modulate reactivity and/or physical properties. Strategies for controlling the activity and stability of metalloproteins will be a primary focus.
3. New Spectroscopic and Theoretical Methods for Metalloprotein Design: Advances in metalloprotein design require concomitant developments in spectroscopic and theoretical methods. These methods have proven essential for gaining an understanding of both biological systems and synthetic analogs. A broad range of approaches will be highlighted.
4. Molecular Design of Nanobiomaterials and Medicinal Materials: The design of new materials that modulate biological activity through metal-biomolecule interactions are a rapidly evolving area of materials chemistry directed towards developments of new biodevices and medicinal agents. The control of metal complexation and distribution is a primary interest in this area.
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